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Heparin - 5 Vials x 5 ml (5000 IU)

Heparin - 5 Vials x 5 ml (5000 IU)

Package: 5 Vials x 5 ml (5000 IU)

Usage: Injectable

It is used to stop blood clots forming within the blood vessels


Price:  $79.00
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Brand names: Hep-Pak, Heparin Lock Flush, Hep-Pak CVC, Hep-Lock, Heparin Sodium ADD-Vantage.
Generic Name: heparin (HEP a rin).

Heparin belongs to the medicine groups known as anticoagulants. A question appears: which is the action of an anticoagulant? The action of anticoagulants is stopping coagulation; in other words, it stops blood from clotting. But it can't decrease the size of the blood clots that have been already developed. It is essentially to notice that this medication has other functions too. The most important purpose of this product is to fight against invading bacteria and other foreign materials.
This medication is administrated by injection into a vein or under the skin (subcutaneously). It should not be injected into a muscle.

Structure of Heparin
Heparin is composed of a variably sulfated repeating disaccharide unit. The most common disaccharide unit is composed of a 2-O-sulfatediduronic acid and 6-O-sulfated, N-sulfated glucosamine, IdoA(2S)-GlcNS(6S). For example, it makes up 85% of heparins from beef lung and about 75% of those from porcine intestinal mucosa.
The major sugars which occur in this medicine are listed below:
α-L-iduronic acid 2-sulfate;
2-deoxy-2¬sulfamino-α-D-glucose 6-sulfate;
β-D-glucuronic acid;
2-acetamido-2-deoxy-α-D¬glucose;
α-L-iduronic acid.
The sugars enumerated above are present in decreasing amounts, usually in the order (2) > (1) > (4) > (3) > (5). Heparin is strongly acidic because of its content of covalently linked sulfate and carboxylic acid groups.

Mechanism of action of heparin
It has been already noticed that this preparation stops blood from clotting. How does it work? It inactivates thrombin. In order to neutralize thrombin heparin binds itself to the coagulation enzyme and antithrobin. The activated antithrombin neutralizes thrombin and other proteases caused blood clotting. Thus, wee understand that antithrombin prevents coagulation by neutralizing proteins that participate in the coagulation cascade.

Administration of Heparin
Heparin is used in case of dialysis, during extracorporeal circulation ardiopulmonary bypass for heart surgery.
Heparin is utilized to cure patients with following illnesses:
peripheral occlusive disease;
thromboprophylaxis;
acute coronary syndrome;
atrial fibrillation;
deep-vein thrombosis and pulmonary embolism.

Heparin dosage
The prescribed dose of heparin henges on some conditions. The dose is henges on the coagulation test results. These tests must be performed enough frequently. The determination of coagulation time henges upon specific factors. When this medication is administrated by continous intravenous infusion, the coagulation tests have to be performed approximately every four hours in the early stages of treatment. When the drug is used intermittently by intravenous injection, coagulation tests are to be done before each injection during the early stages of treatment.
In case of deep vein Thrombosis – Prophylaxis usual the prescribed dose is 5000 units under the skin each 8 to 12 hours.
Usual dose for anticoagulation during pregnancy is 5000 units subcutaneously every 12 hours.
Usual adult dose for thrombotic disorder is100 units/mL each 6 to 8 hours for PVC catheters and peripheral heparin locks. But when stagnant blood is noticed in catheter after it was utilized for medication or blood administration, it is necessary to add flushes. The dosage for babies who have thrombotic disorder is 10 units every 6 to 8 hours. Child dose in this case is 100 units/mL each 6 to 8 hours. Additional flushes must be given when stagnant blood is observed in catheter, after catheter is used for medication or blood administration.
If a person has a massive pulmonary embolism, the initial dosage may be an IV bolus of 10,000 units which are followed by 1500 units per hour.

Probable adverse consequences of heparin
Heparin, as each drug is able to cause adverse reactions. A lot of patients administrating this medication do not have got serious adverse reactions. Some common adverse consequences of heparin are following: swelling at injection site, bone pain, easily broken bones. Pain and loss of feeling in the arms and legs, change in color of the arms and legs, chest pain, difficult breathing, confusion, weakness on one side of the body, slurred speech, vision changes.
Heparin can cause some other side symptoms: signs of severe bleeding, including unusual pain, swelling, discomfort, prolonged bleeding from cuts, persistent nosebleeds, unusually heavy and long-term menstrual periods, unusual easy bruising, dark urine, black stools, serious headache, unusual dizziness.
Serious allergic reactions were registered rarely, but sometimes they may be caused. If you utilize this medicine and notice such consequences as rash, itching, swelling, severe dizziness, difficult breathing and others, consult your pharmacist.
There are such unwanted consequences that are caused in case of long-term Heparin utilizing; others can be results of a systematic administration of this medication. For example, osteoporosis may be caused by long-term administration of high dosages of heparin, cutaneous necrosis has been reported after systemic using; inhibition of aldosterone synthesis, delayed transient alopecia, priapism, and rebound hyperlipemia on ceasing of this medicine have also been reported.
Important elevations of aminotransferase grades have occurred in a high percentage of patients and healthy people who have administrated heparin.

Coumadin and Heparin
Coumadin and Heparin are anticoagulants, so they both stop blood from clotting. They are administrated to cure such diseases as embolism and thrombosis. However they sound similar, coumadin and heparin have a lot of differences. As for adninstrating them, coumadin is taken orally, heparin is usedin a form of injection. Coumadin must not be administrated during pregnancy, heparin can be used by pregnant women. Coumadin and heparin can lead to excessive bleeding that may be life-threatening.

Heparin recall
Firstly, let metion what drug recalls are. Medication recalls are such actions which are taken in order to remove some medicines from the market.
As for Heparin, the most of recalls were in 2008 as a result of unwanted results of heparin which was manufactured in China.
But there were no any recalls related to heparin which was manufactured by B. Braun Medical Inc. B.Braun manufacturer advices to stop heparin administration and contact your pharmacist, if any undesirable consequences are noticed.

Heparin-induced thrombocytopenia
Heparin-induced thrombocytopenia (HIT) is a form of thrombocytopenia which was caused by utilizing of heparin. So, it is a adverse consequence that was produced by heparin administration. There are two types of Hit: type 1 and type 2. HIT type 2 is a more severe side consequence than HIT type 2. HIT type 2 can be a life-threatening aspect. In order to confirm that a person has HIT, he should perform certain laboratory tests.

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